The research group of Dr Ian Harrison (Harrison Lab) is seeking a PhD student to investigate how early-life surgery affects glymphatic function in the brain and whether these changes contribute to the development of dementia-related pathology later in life.

The studentship will be primarily supervised by Dr Ian Harrison, based within UCL’s Division of Medicine at the Centre for Advanced Biomedical Imaging (CABI). CABI is a world-leading facility for in vivo imaging of glymphatic function in preclinical models. The project will also be co-supervised by Dr Simon Beggs in UCL’s Department of Developmental Neuroscience.

Located in a purpose-built facility in central London, CABI offers a range of specialised experimental imaging technologies and infrastructure. The successful candidate will join a multidisciplinary research environment at UCL, bringing together expertise in glymphatic biology, neurodegeneration and developmental neuroscience. With access to state-of-the-art imaging facilities and opportunities to develop advanced experimental skills, UCL provides an outstanding setting in which to investigate the mechanisms linking early-life experiences, brain health and neurodegenerative disease.

About the role

The successful applicant will be a highly motivated and enthusiastic individual with, or nearing completion of, a master’s degree in neuroscience, biomedical sciences, physiology or a related discipline. They will have a strong interest in neuroscience, glymphatic function and neurodegenerative disease, and a desire to develop their research skills through an interdisciplinary PhD project.

The student will investigate how early-life surgery affects glymphatic function in the brain and whether these effects contribute to the development or progression of dementia-related pathology later in life. The project will involve preclinical models and may incorporate a range of experimental approaches, including in vivo imaging, behavioural testing, histology and molecular analysis. The successful candidate will have the opportunity to develop expertise in these techniques while exploring potential mechanisms linking early-life experiences, brain clearance pathways and neurodegeneration.

We are seeking a candidate with strong organisational, communication and interpersonal skills, a proactive approach to learning, and the ability to work both independently and collaboratively within a multidisciplinary research team. Previous research experience in neuroscience or a related field is essential. Above all, the candidate should demonstrate scientific curiosity, enthusiasm for the project and a willingness to learn new techniques and approaches.

About you

We are seeking a curious, enthusiastic and highly motivated individual with a strong interest in neuroscience, brain ageing and neurodegenerative disease. The ideal candidate will be keen to explore how early-life experiences influence brain function and may contribute to the development of dementia-related pathology later in life.

The successful applicant will have strong communication, organisational and problem-solving skills, a willingness to learn new experimental techniques, and the ability to work effectively both independently and as part of a collaborative, multidisciplinary research team. They will be able to think critically about scientific questions, demonstrate initiative and perseverance when faced with challenges, and communicate their findings clearly and effectively.

A background in neuroscience, biomedical sciences, physiology or a related discipline is expected, and previous research experience in neuroscience or a related field is essential. Experience with animal models, imaging or laboratory-based research would be particularly valuable. Above all, we are looking for someone who is eager to develop as a researcher, embrace new challenges and contribute to research advancing our understanding of the mechanisms linking early-life experiences to neurodegenerative disease.

What we offer

This is an opportunity to join a multidisciplinary team working across the Division of Medicine. As well as the opportunities this role presents, we also offer further benefits some of which are below:

41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days)
Cycle to work scheme and season ticket loan

Immigration loan

On-site nursery
On-site gym
Employee assistance programme: Staff Support Service
Discounted medical insurance

Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.

Our commitment to Equality, Diversity and Inclusion

As London’s Global University, we know diversity fosters creativity and innovation. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong.

We particularly encourage applications from candidates underrepresented in UCL’s workforce, including those from Black, Asian and ethnic minority backgrounds, disabled people, and – for Grade 9 and 10 roles – women.

Read more: UCL Equality, Diversity and Inclusion.

Applicants should also familiarise themselves with UCL’s policies on: Prevention of Bullying, Harassment and Sexual Misconduct Policy and Personal Relationships Policy

Our department holds an Athena SWAN Silver award, in recognition of our commitment and demonstrable impact in advancing gender equality