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Job Post Details

Technical Lead, Medicines Safety Technologies - £78,230 - £87,809 p.a. + benefits
Medicines and Healthcare Products Regulatory Agency
·
3.8
10 South Colonnade, London E14
£78,230 a year
Permanent, Full-time
Apply on company site

Job details

£78,230 a year
Pay rise, Childcare, Annual leave, Sick pay, Company pension, Season ticket loan
Permanent, Full-time
10 South Colonnade, London E14

Full job description

Details

Reference number

487067

Salary

£78,230
New entrants to the Civil Service will start their role on the salary band minimum of £78,230
A Civil Service Pension with an employer contribution of 28.97%
GBP

Job grade

Grade 6

Contract type

Permanent

Business area

MHRA - Safety and Surveillance Group - Benefit Risk Evaluation I

Type of role

Other

Working pattern

Flexible working, Full-time

Number of jobs available

1

Contents

  • Location
  • About the job
  • Benefits
  • Things you need to know
  • Apply and further information

Location

10 South Colonnade, Canary Wharf London, E14 4PU.

About the job

Job summary

We are currently looking for a Technical Lead, Medicines Safety Technologies to join our Benefit Risk Evaluation I Function within the Safety & Surveillance Group.

This is a full-time opportunity, on a permanent basis. The role will be based in 10 South Colonnade, Canary Wharf London, E14 4PU.

Government departments and agencies are working towards implementing a minimum 60% attendance in office sites.

We are currently implementing a flexible, hybrid way of working, with a minimum of 8 days per month working on site to enable the collaboration and contact with partners and stakeholders needed to deliver MHRA business. Attendance on site is driven by business needs so depending on the nature of the role, this can flex up to 12 days a month, with the remainder of time worked either remotely or in the office. Some roles will need to be on site more regularly. Remote working is potentially available for some specific roles. Please discuss this with the recruiting manager before accepting an appointment.

The Safety and Surveillance (S&S) Group brings together into a single integrated structure expertise on the safety of all medical products with enforcement capabilities. These functions are supported by the Agency’s data and evidence generating capabilities, complementing our signal generating abilities.

Against this background and the drive to improve treatment availability for patients, safety remains at the heart of all our decision making across the product life cycle. The central mission of the Safety & Surveillance portfolio is to protect the public by appropriately identifying, assessing and managing the risks associated with medical products. In every aspect of this work, we harness the best science, technology, information and professional practice to protect patients in new and impactful ways.

The core purpose of Benefit Risk Evaluation is to deliver a robust assessment of potential safety signals using data from a range of sources along with technical, scientific, clinical and regulatory knowledge, and practical experience. The team conducts benefit-risk evaluations for medicines and medical device across a broad spectrum of therapeutic areas to guide actions that protect patient safety. The team is responsible for:

  • Signal detection of emerging safety issues
  • Evaluating the benefit risk of signals and developing effective and measurable risk mitigation measures
  • Using data and embracing new technologies to develop the evidence to support our actions and understand their impact

Job description

Role Purpose

This is an exciting opportunity to play a senior technical leadership role in the MHRA's pioneering regulatory sandbox, “Beyond ADMET: AI for Medicines Safety”, an innovative initiative exploring how artificial intelligence can transform medicines development and strengthen patient safety. Working alongside the Head, AI for Medicines Safety, you will provide specialist scientific and technical leadership, helping to shape the evidence, methodologies and innovations that inform future regulatory approaches. This is a unique opportunity to work at the intersection of AI, toxicology, pharmacology, medicines development and regulatory science while contributing to the MHRA's wider ambitions for AI-enabled innovation and patient safety.


Key Responsibilities

  • Provide senior scientific and technical leadership for the “Beyond ADMET: AI for Medicines Safety” Sandbox programme, ensuring programme activities are scientifically robust, technically credible and aligned with regulatory objectives.
  • Work in partnership with the Head, AI for Medicines Safety to ensure the programme benefits from complementary expertise across artificial intelligence, healthcare data science, toxicology, pharmacology, medicines development and regulatory science.
  • Lead the evaluation of emerging methodologies, technologies, datasets and evidence relevant to AI-enabled medicines development, safety assessment and regulatory decision-making.
  • Build and maintain strong relationships with experts across the MHRA, industry, academia and government, representing the programme through technical engagement, collaboration and thought leadership activities.

Person specification

Essential Criteria:

  • Significant experience and recognised expertise in at least one of the following areas:
    • Pre-clinical assessment, toxicology and New Approach Methodologies (NAMs)
    • Artificial Intelligence and Machine Learning
    • Healthcare data science and computational modelling
    • Pharmacology, drug discovery or development
    • or related scientific areas.
  • Experience applying scientific and technical expertise to complex regulatory, healthcare, research or industry challenges; and evaluating scientific evidence and translating findings into practical recommendations and actions.
  • Experience working with multidisciplinary teams involving scientific, technical and non-technical stakeholders, and engaging effectively with external stakeholders, including academia, industry and research organisations.
  • Experience preparing technical reports, scientific assessments, briefings, publications or regulatory submissions.

Behaviours

We'll assess you against these behaviours during the selection process:

  • Communicating and Influencing
  • Working Together
  • Delivering at Pace

Technical skills

We'll assess you against these technical skills during the selection process:

  • Degree in a relevant scientific, technical or healthcare discipline (or equivalent experience).
  • Postgraduate qualification (MSc, PhD or equivalent experience) in a relevant field such as artificial intelligence, computational biology, pharmacology, toxicology, data science, bioinformatics, pharmaceutical sciences or a related discipline.
  • Recognised technical expertise in either: Pharmacology, Toxicology, Drug Development, Safety Science, New Approach Methodologies (NAMs) or related disciplines, OR AI, Machine Learning, Healthcare Data Science, or related disciplines
  • Ability to critically evaluate scientific evidence, AI methodologies, model performance and validation approaches.
  • Strong analytical skills and the ability to interpret complex scientific, technical and data-driven information.
  • Excellent written and verbal communication skills, including the ability to communicate highly technical concepts to diverse audiences.

We only ask for evidence of these technical skills on your application form:

  • Recognised technical expertise in either: Pharmacology, Toxicology, Drug Development, Safety Science, New Approach Methodologies (NAMs) or related disciplines, OR AI, Machine Learning, Healthcare Data Science, or related disciplines

Benefits

Alongside your salary of £78,230, Medicines and Healthcare Products Regulatory Agency contributes £22,663 towards you being a member of the Civil Service Defined Benefit Pension scheme. Find out what benefits a Civil Service Pension provides .
  • Annual Leave: 25 days annual leave on entry, rising by one day for each completed year of service to a maximum of 30 days and pro-rata for part-time staff. PLUS 8 bank holidays
  • Privilege Leave: 1 day
  • Hours of Work: 37 hours (net) per week for full time staff in all geographical locations, including London and pro rata for part-time staff
  • Occupational Sick Pay (OSP): One month full pay/one month half pay on entry, rising by one month for each completed year of service to a maximum of six months full pay and six months half pay after five years’ service.
  • Mobility: Mobility clause in contracts allowing staff to be mobile across the Civil Service
  • Civil Service Pension Scheme. Please see the link for further information http://www.civilservicepensionscheme.org.uk/ For enquiries relating to the Civil Service Pension Schemes please contact MyCSP's Pension Service Centre directly on 0300 123 6666
  • Flexible working to ensure staff maintain a healthy work-life balance
  • Interest free season ticket loan or bike loan
  • Employee Assistance Services and access to the Civil Service Benevolent Fund
  • Eligibility to join Motoring , Boundless by CSMA
  • Variety of staff and Civil Service clubs
  • On-going learning and development

Things you need to know

Artificial intelligence

Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be withdrawn and internal candidates may be subject to disciplinary action. Please see our candidate guidance for more information on appropriate and inappropriate use.

Selection process details

This vacancy is using Success Profiles , and will assess your Behaviours, Strengths, Experience and Technical skills.

Key dates

  • Closing date – 15 November 2026 at 23:55
  • Sifting – from 16 November 2026
  • Main panel interviews – w/c 07 & 14 December 2026

Communications will be electronic via email therefore it is important that you check your Civil Service Jobs account regularly, as well as your spam/junk email folder.

We’re committed to being diverse and inclusive, so please make your application anonymous by removing all identifying personal information (such as names and dates) from your employment history and personal statement.

What will the process look like?

1. Pre-sift Stage

An initial sift will be conducted on the experience question which has a word limit of 500 words. If you are assessed as not meeting the required level, you will not be progressed past this stage.

Question: "Describe one project, programme or research initiative where you acted as the recognised technical lead in one of the following areas: AI/ML, Healthcare Data Science, Computational Modelling, Pharmacology, Toxicology, Drug Development, Safety Science, or NAMs. Responses should clearly demonstrate your technical expertise, level of accountability, and impact of the work" (maximum 500 words).

2. Sift Stage

  • Anonymised CV which sets out your career history, previous experience and skills, highlighting specific responsibilities that are relevant for this role.
  • Online application form, including questions based on the Behaviour, Experience and Technical Success Profiles. Please ensure all application questions are completed in full; your application may not be considered if any responses are left blank.

The panel will look at your application and are looking for evidence of the stated points. We may raise the benchmark score required if we receive a high number of applications.

2. Main Panel Interview

Successful candidates from the sift stage will be invited to attend an interview. We use a blended interview technique, allowing us to find out more about you. We use the Success Profile framework and at interview we will be assessing Behaviours and Experience.

Your interview will include:

  • Presentation, to be prepared as part of your interview, with further information being supplied when you reach this stage.

At interview, we will be asking questions relating to the following:

  • Behaviours, as listed in the person specification
  • Experience, as listed in the person specification
  • Strengths

The panel will look at your application and are looking for evidence of the stated points. We may raise the benchmark score required if we receive a high number of applications.

If you require any disability related adjustments at any point during the process, please contact careers@mhra.gov.uk as soon as possible.

Candidates will be subject to UK immigration requirements as well as Civil Service nationality rules. Further information on whether you are able to apply is available here.

Successful candidates must pass a disclosure and barring security check as well as animal rights and pro-life activism checks. People working with government assets must complete basic personnel security standard checks.


Certain roles within the MHRA will require post holders to have vaccinations, and in some circumstances, routine health surveillance. These roles include:

  • Laboratory-based roles working directly with known pathogens
  • Maintenance roles, particularly those required to work in laboratory settings
  • Roles that involve visiting other establishments where vaccination is required
  • Roles required to travel overseas where specific vaccination may be required.

Applicants who are successful at interview will be, as part of pre-employment screening subject to a check on the Internal Fraud Database (IFD). This check will provide information about employees who have been dismissed for fraud or dishonesty offences. This check also applies to employees who resign or otherwise leave before being dismissed for fraud or dishonesty had their employment continued. Any applicant’s details held on the IFD will be refused employment. A candidate is not eligible to apply for a role within the Civil Service if the application is made within a 5 year period following a dismissal for carrying out internal fraud against government.

Any move to the MHRA from another employer will mean you can no longer access childcare vouchers. This includes moves between government departments. You may however be eligible for other government schemes, including Tax-Free Childcare. Determine your eligibility here.

Individuals appointed on level transfer will retain their existing salary and are responsible for ensuring they fully understand the financial implications of any potential move and the impact (if any) on their terms. If an individual is in any doubt, they should seek clarification before accepting a job offer.

Staff joining on promotion will receive up to a 10% increase of their current basic salary, or the pay band minimum, whichever is the greater.

The individual will not retain any allowances paid by the former department/Agency, unless there are special circumstances, such as a reserved right to those allowances on transfer.

Successful candidates may be subject to annual Occupational Health reviews dependent on role requirements. If you have any queries, please contact careers@mhra.gov.uk.




Feedback will only be provided if you attend an interview or assessment.

Security

Successful candidates must undergo a basic (or equivalent) criminal record check.
People working with government assets must complete baseline personnel security standard (opens in new window) checks.

Nationality requirements

This job is broadly open to the following groups:

  • UK nationals
  • nationals of the Republic of Ireland
  • nationals of Commonwealth countries who have the right to work in the UK
  • nationals of the EU, Switzerland, Norway, Iceland or Liechtenstein and family members of those nationalities with settled or pre-settled status under the European Union Settlement Scheme (EUSS)
  • nationals of the EU, Switzerland, Norway, Iceland or Liechtenstein and family members of those nationalities who have made a valid application for settled or pre-settled status under the European Union Settlement Scheme (EUSS)
  • individuals with limited leave to remain or indefinite leave to remain who were eligible to apply for EUSS on or before 31 December 2020
  • Turkish nationals, and certain family members of Turkish nationals, who have accrued the right to work in the Civil Service
Further information on nationality requirements

Working for the Civil Service

The Civil Service Code sets out the standards of behaviour expected of civil servants.

We recruit by merit on the basis of fair and open competition, as outlined in the Civil Service Commission's recruitment principles .
The Civil Service embraces diversity and promotes equal opportunities. As such, we run a Disability Confident Scheme (DCS) for candidates with disabilities who meet the minimum selection criteria.
The Civil Service also offers a Redeployment Interview Scheme to civil servants who are at risk of redundancy, and who meet the minimum requirements for the advertised vacancy.

Diversity and Inclusion

The Civil Service is committed to attract, retain and invest in talent wherever it is found. To learn more please see the Civil Service People Plan and the Civil Service Diversity and Inclusion Strategy .

Apply and further information

This vacancy is part of the Great Place to Work for Veterans initiative.
Once this job has closed, the job advert will no longer be available. You may want to save a copy for your records.

Contact point for applicants

Job contact :

  • Name : The Resourcing Team
  • Email : Careers@mhra.gov.uk

Recruitment team

  • Email : Careers@mhra.gov.uk

Further information

In accordance with the Civil Service Commissioners’ Recruitment Principles our recruitment and selection processes are underpinned by the requirement of selection for appointment on the basis of merit by a fair and open competition. If you feel your application has not been treated in accordance with the Recruitment Principles and you wish to make a complaint, you should contact the Resourcing team at Careers@mhra.gov.uk, in the first instance. If you are not satisfied with the response you receive you can contact the Civil Service Commission at: civilservicecommission.independent.gov.uk - info@csc.gov.uk - Civil Service Commission Room G/8 1 Horse Guards Road London SW1A 2HQ

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