Bioarchitech is a small biotechnology company developing cancer immunotherapies based on oncolytic viruses and self-amplifying RNA (saRNA) technologies. We are seeking a Senior Scientist with in vivo cancer model experience to drive the characterisation, and evaluation of our immunotherapies.

This is an opportunity to work in a small team and therefore have exposure to many aspects of a small biotech company. Reporting directly to Head of Platform Development and working closely within a small R&D team, you'll play a key role in advancing our preclinical programmes towards clinical trials. You will also have the opportunity to oversee contract research organisations (CROs) that conduct in vivo studies of our immunotherapy candidates.

You will have a doctorate degree (or equivalent experience) in immunology, oncology or related biological science. The role is laboratory-based, and it is essential that you have been a PIL holder for at least 3 years, you should have experience with various routes of administration such as intravenous, subcutanous and intraperitoneal . Experience in using mouse models of cancer, immunotherapy or surgical procedures with recovery would be desirable. The role will be an equal mix of in vitro and in vivo work. You will keep careful and accurate records in an electronic notebook so that your results may be published in the future and be referenced by regulatory authorities.

All applicants must provide a CV including contact details for at least two referees which we will only contact if shortlisted for interview.

The company is located at the Wood Centre for Innovation, Headington, Oxford. Access by public transport or cycle is strongly encouraged as car parking is not readily available.

Benefits: 5% of salary employer pension contribution. 25 days holiday per year + bank holidays, company share option scheme, cycle to work scheme.

Qualifications and experience:

Must have a PhD or equivalent experience in Immunology, oncology or a related biological science.
Be or have been a Home Office PIL holder for 3+ years and be able to work independently doing so.
Demonstrated experience in data analysis, visualisation, and statistical interpretation (e.g., GraphPad Prism, FlowJo) and proficiency in Microsoft Office (Word, Excel).
At least 3 years’ experience with mammalian cell culture and immunological assays. Preferably have experience of working with viruses
Proven ability to design, organise, and run research projects independently

Tasks and Responsibilities:

To design, plan and carry out experimental research into testing of recombinant vaccinia virus and saRNA, including in vitro and in vivo experiments.
To oversee contract research organisations conducting in vivo experiments from study design through data interpretation.
To perform common laboratory techniques including cellular assays, RNA or DNA purification, PCR, qPCR, ELISA, ELISpot, Incucyte imaging, basic microscopy, flow cytometry.
To produce and maintain cell lines using sterile techniques.
To develop detailed written protocols suitable for transfer to contract research organisations and contract manufacturing organisations.
To participate in and prepare presentations for scientific meetings.
Keep accurate, audit-ready records (day books and electronic systems) to support future publications and regulatory submissions.
To carry out support functions when required (e.g., metrology, cleaning, material receipt, data checking).
To assist in the day to day running of the laboratory such as maintaining stocks of consumables, liaising with suppliers for quotations and sample storage spreadsheets.
To ensure that all work is performed in compliance with company health and safety policies and current legislation.
To attend training courses (if any) as may be required.
To share and work effectively with other team members.
To perform other duties as required by the company management.

Pay: £40,000.00-£55,000.00 per year

Benefits:

Company pension
Cycle to work scheme
Sick pay

Application question(s):

Briefly list the types of in vivo procedures you have experience in, especially interested to know if have used i.v., i.p or s.c injections, tumour models, live whole body imaging such as IVIS, minor surgery with recovery?

Education:

Bachelor's (required)

Licence/Certification:

or previously held a Home Office PIL (required)

Work authorisation:

United Kingdom (required)

Work Location: In person

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