Clinical Trials jobs in Buckinghamshire

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

The Translational Medicine Lab plays a pivotal role at Immunocore, generating biological data from both clinical trial and pre-clinical experimental samples in order to advance understanding of our platform and ultimately improve patients' health. We are looking for an enthusiastic Associate Scientist to join our team. The successful candidate will gain experience in several advanced techniques and provide essential support for multiple projects aimed at understanding the mechanism of action of our therapeutics.

Key Responsibilities:

• Perform and contribute to development of experiments using primary cancer cells, PBMCs and tumour cell lines, to understand candidate molecule effects on T cell activation and tumour killing.
• Provide support to ongoing experimental projects (eg maintaining cell cultures, isolating cell populations, and performing immunoassays such as ELISA, ELISpot, killing assays, microscopy and flow cytometry).
• Provide cell sorting support to isolate different immune cell subsets from blood and tumour biopsies.
• Maintain equipment and keep experimental and maintenance records in accordance with HTA and /or GCP standards, as relevant
• Present and interpret results at internal lab and departmental meetings

Education, Experience and Knowledge:

Essential Qualifications:

• BSc or MSc with relevant experience in Immunology, Cancer Biology or related field
• Aseptic cell culture techniques
• Experience in working with a wide range of immunoassays
• Knowledge in T cell immunology or cancer biology
• Knowledge and skills of using standard laboratory equipment
• Ability to design and conduct lab-based experiments
• Ability to technically analyse and report results
• Good communication and organisational skills
• Ability to work with diverse team members

Desirable

• Experience with 3D models (spheroids and organoids)
• Experience in cell sorting capabilities and immune cell subset isolation
• Experience with processing and analysing clinical samples
• Experience in application of GCP/HTA principles